GWAS challenge Saturday, Sep 19 2009 


Making causative connections between genotypic and phenotypic variation is a major challenge for geneticists engaged in the study of human disease. A study drawing this connection for a type 1 diabetes risk locus now demonstrates the importance of focusing on specific quantitative traits and studying them in normal subjects.


Over the last few years, genome-wide association studies (GWAS) have reported an extraordinary harvest of new genetic associations. This productivity has been particularly rich in the area of human autoimmune disorders, where in the aggregate well over 100 confirmed associations have been reported in diseases including type 1 diabetes1, inflammatory bowel disease2 and rheumatoid arthritis, among many others3.


much overlap Monday, Sep 14 2009 

There is much overlap between the genes, pathways and biological processes implicated by the GWAS studies and those identified through these monogenic human and animal model studies (Table 1).

—over·lap Listen to audio /ˈoʊvɚˌlæp/ noun plural over·laps [count] ▪ The map shows an overlap in the regions controlled by the two tribes. [noncount] ▪ There is some overlap between the two courses. [=the courses cover some of the same material]

chief recommendation Sunday, Sep 13 2009 

The chief recommendation arising from the current state of knowledge in the field is for a movement away from reliance on the human-chimpanzee calibration; instead, calibrations within the human tree are preferred (but see [14]).

After the deadline Tuesday, Sep 8 2009 


How to Write With a Knife Monday, Sep 7 2009